In-Depth Precautions and Warning

Drug Warnings

CEFEPIME+TAZOBACTAM should be used with caution in patients with kidney impairment. There is a risk of serious adverse events such as confusion, hallucinations, stupor (a state of near-unconsciousness), and seizures (fits). CEFEPIME+TAZOBACTAM may cause Clostridium difficile associated diarrhoea (CDAD), ranging from mild diarrhoea to fatal colitis (inflammation of the large intestine). If CDAD is suspected or confirmed, the doctor may discontinue therapy and advise appropriate fluid and electrolyte management, protein supplementation, and antibiotic therapy to treat CDAD. A CEFEPIME+TAZOBACTAM may cause positive direct Coomb’s test, which indicates antibodies against red blood cells. So, it is necessary to let your doctor know that you are taking this medicine before undergoing laboratory tests. Do not discontinue or abruptly stop the medication as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. CEFEPIME+TAZOBACTAM may cause superinfection (additional infection caused by other microbes) on prolonged use.

Drug Interactions

Drug-Drug Interactions: CEFEPIME+TAZOBACTAM may interact with aminoglycoside antibiotics (streptomycin, neomycin, and gentamicin) as it may cause severe nephrotoxicity (damage to the kidney). It may also interact with a medicine used to treat gout (probenecid).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: CEFEPIME+TAZOBACTAM should be used with caution in patients with kidney problems, gastrointestinal problems, especially colitis (inflammation of the large intestine) and diabetes.

Safety Advice

  • ALCOHOL
    CEFEPIME+TAZOBACTAM may interact with alcohol. Consult your doctor before consuming any alcohol.
  • PREGNANCY
    CEFEPIME+TAZOBACTAM is a category B medicine and may not cause harmful effects to the unborn baby. However, it should be used in pregnant women only if prescribed by a doctor.
  • BREAST FEEDING
    CEFEPIME+TAZOBACTAM may pass into breast milk in small amounts. So, caution should be exercised when given to breastfeeding mothers.
  • DRIVING
    CEFEPIME+TAZOBACTAM may not affect your ability to drive.
  • LIVER
    CEFEPIME+TAZOBACTAM should be used with caution in patients with live diseases. The dose may have to be adjusted by your doctor.
  • KIDNEY
    CEFEPIME+TAZOBACTAM should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.